(Funded by the Focused Ultrasound Surgery Foundation number, NCT01304758.). Large, randomized, controlled trials will be required to assess the procedure's efficacy and safety. In this pilot study, essential tremor improved in 15 patients treated with MRI-guided focused ultrasound thalamotomy. Quality-of-life scores improved from 37% to 11% (P=0.001). Disability scores improved from 18.2 to 2.8 (P=0.001). Total tremor scores improved from 54.9 to 24.3 (P=0.001). Scores for hand tremor improved from 20.4 at baseline to 5.2 at 12 months (P=0.001). Adverse effects of the procedure included transient sensory, cerebellar, motor, and speech abnormalities, with persistent paresthesias in four patients. Thermal ablation of the thalamic target occurred in all patients. We assessed the patients' perceptions of treatment efficacy with the Quality of Life in Essential Tremor Questionnaire (ranging from 0 to 100%, with higher scores indicating greater perceived disability). We recorded all safety data and measured the effectiveness of tremor suppression using the Clinical Rating Scale for Tremor to calculate the total score (ranging from 0 to 160), hand subscore (primary outcome, ranging from 0 to 32), and disability subscore (ranging from 0 to 32), with higher scores indicating worse tremor. This preliminary study investigates the use of transcranial MRI-guided focused ultrasound thalamotomy for the treatment of essential tremor.įrom February 2011 through December 2011, in an open-label, uncontrolled study, we used transcranial MRI-guided focused ultrasound to target the unilateral ventral intermediate nucleus of the thalamus in 15 patients with severe, medication-refractory essential tremor. For details on the safety results of Insightec-sponsored clinical studies, please click here.Recent advances have enabled delivery of high-intensity focused ultrasound through the intact human cranium with magnetic resonance imaging (MRI) guidance.
Patients considering treatment should discuss with a physician all treatment options available and risks involved. Overall, Focused Ultrasound is a reasonably safe procedure with minimal risks. Parameters can be adjusted to ensure optimal response tailored just to you, and you can often go home the very same day. The treatment is guided by MRI, which acts as the “eyes” of the treatment so the physician can target the precise spot in the brain. Physicians are treating hand tremor from Essential Tremor or Tremor-dominant Parkinson’s Disease with the therapeutic power of focused ultrasound - typically in just one outpatient procedure. A single outpatient treatment that fits into your life. 1 Life-changing transformations are taking place all over the world thanks to innovation in medical technology by Insightec. Shaking hands should not have to be a part of aging and can be treated effectively when medications don’t provide satisfactory relief. Patients must be at least 22 years of age. Approval is for treatment of one side of the brain only. MR-guided focused ultrasound is approved for the treatment of essential tremor that cannot be controlled with medication. For details on the safety results of Insightec-sponsored clinical studies, please click here.įor Patients and Caregivers It’s time to get back on the path of aging well. Food and Drug Administration has approved focused ultrasound for the following conditions: Essential tremor. 1 Patients considering treatment should discuss with a physician all treatment options available and risks involved.
How does focused ultrasound work We use ultrasound to ablate (burn) the part of your brain that causes tremor.
Parameters can be adjusted to ensure optimal response, and patients typically go home the very same day. To schedule an evaluation for focused ultrasound treatment for essential tremor or tremor-dominant Parkinson’s disease, call our clinic at 50, or email us at. The treatment is guided in real-time by MRI, providing patient-specific treatment planning, as well as continuous temperature monitoring for safety and efficacy. From patient-specific planning to sub-millimeter precision, this incision-free treatment often results in an immediate therapeutic effect with minimal complications. Transform patient lives with Focused Ultrasound.īring a sense of inspiration to your department as you and the clinical team help transform lives. Focused ultrasound allows you to perform precision treatment with the click of a mouse. For Healthcare Professionals The future of Neurosurgery is here.īy harnessing acoustic energy, you can treat Essential Tremor and Tremor-dominant Parkinson’s Disease with the therapeutic power of Exablate Neuro, a Focused Ultrasound platform that is advancing patient care.
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